dementia,

  • Coenzyme Q10

    Coenzym Q10

    Dr. med. Heinz Lüscher

     

    Many people know Q10 from the advertising for anti-aging care products. But it would be a pity to limit Q10 to its effect on the skin. Q10 is basically needed by every cell in our body to ensure the energy supply. And it can do even more!

    What is Coenzyme Q10?

    Coenzyme Q10, also known as Q10, ubiquinone-10 or UQ, is a fat-soluble molecule that is similar in structure to vitamin K and vitamin E. Most people are familiar with Q10 from advertising for anti-aging products, so many think it is just a beauty product. However, it can do much more than ensure a firm skin, which is not bad at all.

    Cell-Energy

    Ubiquinone is a very important endogenous coenzyme that occurs in every cell of the body (ubiquitous = everywhere) and has a decisive influence on the formation of the universal body energy ATP (Adenosine Tri-Phosphate). Q10 is one of the crucial nutrients for energy production in the tiny but powerful mitochondria. These are the power plants that work for us in each and every one of our body cells. In the mitochondria, the energy we consume via carbohydrates, fats or proteins is converted into ATP together with oxygen and the power of water. This process, in which many other enzymes and vital substances are involved, is also called the respiratory chain. Coenzyme Q10 plays an important role in the last step of the respiratory chain. Most Q10 is needed by organs with high energy consumption such as the brain, heart, liver, kidneys, pancreas and, in sports, the muscles. However, Q10 is basically urgently needed by every cell in our body to ensure the energy supply.

    But it can do even more!

    Main effects of Q10

    • Promotes the formation of the cell energy ATP
    • Acts antioxidative
    • Stabilizes the cell walls
    • Stabilizes the walls of the mitochondria
    • Strengthens the immune system
    • Protects the nerve cells (neuroprotective)
    • Protects the heart muscle cells (cardioprotective)

    Q10 deficiency

    Even a Q10 deficiency of 25% causes damage to the mitochondria, the tiny cell organelles that produce ATP, which can lead to a noticeable loss of energy. In the course of life, the body's own production decreases continuously. With an increasing deficiency of Q10, the risk of disease also increases. One example is dementia: every brain cell has hundreds to thousands of mitochondria that depend on Q10! The lower the Q10 level, the greater the risk of dementia. Q10 also inhibits inflammation and intercepts free radicals (antioxidant), which is also important in the prevention of dementia.

    Sources of coenzyme Q10

    Q10 is the only fat-soluble antioxidant that can be produced by our body itself. However, this amount is too small, so we have to supplement Q10 with our food. However, there is no food that contains a particularly high amount of Q10, so a balanced diet is crucial. Most Q10 is found in the flesh of organs (e.g. liver), oily fish (e.g. sardines), nuts (e.g. pistachios), pulses, sesame seeds, sunflower seeds, vegetable oils, cabbage, onions, potatoes, spinach, Brussels sprouts and broccoli. However, the coenzyme can be destroyed by boiling. Gentle preparation is therefore important.

    When is supplementation with Q10 indicated?

    Supplementation can be recommended as a preventive measure from the age of 50 onwards, especially if problems with reduced energy are already noticeable or if medication is taken which reduces the Q10 level as a side effect. By the way, nobody makes a mistake to be well supplied with Q10. The positive effects e.g. on brain and heart function and life expectancy are proven beyond doubt. If you take Q10 as a dietary supplement, bioavailability is highest when you consume fats at the same time.

    Q10 Predators - drugs

    The cholesterol-lowering statins (CSE inhibitors) and beta-blockers considerably reduce the Q10 level as a side effect, in the case of statins it can be over 50%. Tricyclic antidepressants also lower Q10 levels. Anyone who has to take statins because of high cholesterol (note: a level below 7.0 mmol/l is normal and does not need to be treated, a cholesterol level below 5.0 mmol/l is even more dangerous than too high a level!

    Are there side effects of coenzyme Q10?

    Q10 has no side effects in therapeutic doses up to 2400 mg/day! At even higher doses, which makes no sense therapeutically, diarrhoea and nausea can occur.

    What is the difference between ubiquinone and ubiquinol?

    Ubiquinol is the reduced form of ubiquinone (a reduction is a chemical reaction in which electrons are transferred from one molecule to another). Ubichonol and ubiquinone are 2 states of an identical substance.

    Dosage

    The dosage naturally depends on the disease and its severity, it is between 100 and 500 mg daily. The capsules are taken throughout the day before meals. A lower dose is sufficient for prophylactic replenishment of the Q10 level and is recommended for 3-6 months.

    Recommendations

    Liquid Q10 in soft gel capsules is best absorbed in the intestine. Preference should be given to natural products and not synthetically produced ones. The Q10 Vida, produced with a patented lipid-based process, is very well absorbed in the intestine and the plasma level is significantly higher than with other products during 24 hours. Therefore I gladly recommend this product.

    Here is the study:

    http://www.ncbi.nlm.nih.gov/pubmed/19284181

    Coenzyme Q10 may cause a have a preventive or curative effect:

    Chronic fatigue/weariness

    • Problems of concentration
    • Burnout
    • Depression
    • Dementia/Alzheimer's
    • Parkinson
    • Common infections
    • Obesity
    • ALS
    • Treatment with statins or beta blockers
    • Age over 50
    • Breast cancer under tamoxifen treatment
    • Diabetes
    • Chronic inflammation (e.g. arthritis)
    • Fertility disorders
    • Fibromyalgia
    • Cardiovascular diseases
    • Migraine
    • multiple sclerosis
    • Renal insufficiency
    • Periodontosis

    Further clinical studies

    More than 5000 studies about Q10 are published on pubmed.org

    The most important ones:

    Download Coenzym Q10 Article as a PDF

  • Omega-3-Fettsäuren / Krill-Oil

    Omega-3-fatty acids / Krill Oil

    Dr. med. Heinz Lüscher

     

    What are Omega-3-fatty acids?    

    Omega-3-fatty acids are polyunsaturated fatty acids. They can’t be produced by human body itself, thus, must be obtained through diet. Omega-3 fatty acids can be found in various plants, algae and fishes—in the form of α-linolenic acids and their descendants.

    Alpha-linolenic acids (or α-linolenic acids, also known as ALA) exist in vegetable oil such as linseed oil, rapeseed oil, and in less known oil out of chia- and perilla plants. You can also find them in algal oil, walnuts and leafy vegetables. These fatty acids are preliminary stages of those biologically most active omega-3 fatty acids: eicosapentaenoic acids (EPA) and docosahexaenoic acids (DHA). EPA and DHA exist mainly in fish and in particular type of algae. The human body is generally capable to turn ALA into EPA and DHA, yet only to a limited extent.

     

    What is the importance of Omega-3-fatty acids?  

    Omega-3 fatty acids fulfill a multitude of functionalities. They are essential for various metabolic processes, are components of cell membrane and play a crucial roll in normal growth and development by children.

     

    Omega-3-fatty acids protect the heart

    We’ve known that omega-3-fatty acids lower the risk of sudden cardiac death and prevent further cardiovascular diseases. Studies on human prove the following effects of EPA & DHA:

    • They act as anti-cardiac arrhythmia, i.e. they protect against irregular cardiac rhythm in both upper- and lower chambers of heart: atria and ventricles.
    • They stabilize the unstable blood flow in vessels, which can cause myocardial infarction due to a coronary artery blockage (a build-up of plagues along the inner walls of the arteries).
    • They decelerate the proceeding of abnormal changes in coronary arteries as well as in coronary veins.
    • They help sinking triglyceride levels—a high level of triglycerides in the bloodstream is linked to, and may constitute the risk of thrombosis and atherosclerosis.
    • They have the preventative impact against coronary heart diseases.
    • They accelerate the blood circulation.
    • They inhibit thrombocyte aggregation.
    • And they show a great deal of beneficial effects on vessel functionality, blood pressure as well as against inflammation mediators.

     

    Omega-3-Fatty acids reduce the risks of Dementia

    Omega-3-fatty acids can even sink the risk of dementia diseases—such as its most common type—Alzheimer. Many studies show, that a high-level of EPA and DHA is related to bigger brain volumes. Therefore, the benefit of omega-3-fatty acids becomes significant, due to the fact that brain shrinkage is one crucial factor in dementia progression.

     

    Further application examples

    Omega-3-fatty acids EPA and DHA are attributed to the highly therapeutical impact in treating numerous chronic degenerative and inflammatory diseases. It is general recommended in treating autoimmune diseases and cancer. By multiple sclerosis, for example, omega-3-fatty acids combined with Coenzyme Q10 can at least partially recover the damaged insulating covers of nerve cells, i.e. rebuild the destructed myelin sheaths of neurons. Omega-3-fatty acids used with vitamin D together can regulate the immune system by increasing the number of leukocytes in blood (or so-called “white blood cells”). People ever with returning infections benefit from such adjunctive therapy.

     

    How does krill oil differ from fish oil?


    Although fish oil shows a higher concentration of omega-3-fatty acids in comparison with krill oil, the omega-3-fatty acids in krill oil can however be better absorbed by the body. This is because, whereas the omega-3-fatty acids in fish oil are exclusively attached to its lipid-soluble-only carriers—triglycerides (which is highly hydrophobic), those in krill oil are bound to amphipathic phospholipids, meaning they are soluble in both water and fat. This fact leads to far-reaching results in terms of bodily tolerability, digestion and absorption of the oils. And the typical “fishy” belching phenomenon after intake of fish oil is totally dropped by taking krill oil instead. Further benefits of krill oils are:

    • The ratio between omega-3-fatty acids and omega-6-fatty acids of krill oil is about 3 times higher than that of fish oil.
    • In comparison with fish oil, krill oil contains natural astaxanthin.
    • Krill occupies its position at the lowest trophic level of the food chain. Therefore heavy metals and other toxics can hardly find their way to pass into the body of this organism. Fishes stand, as opposed to krill, further up at the high trophic level of the food chain. The chances of getting their body contaminated by heavy metal or other toxics are obviously much greater.
    • Conversely to many fish species, krill is not threatened by overfishing. The krill population is estimated at approx. 500 million tonnes worldwide, no other animal species in the world is capable to proliferate more than krill. The global krill harvest saturated at about 200’000 tonnes annually, which makes up less than 0.1% of its population. Nonetheless, it is meaningful to only utilize krill from sustainable sources.

     

    What is astaxanthin?

    Astaxanthin is a natural, reddish pigment belongs to the class of carotenoids (such as beta-carotene, zeaxanthin and lutein). It is mainly produced by green algae. It provides the red color of crustaceans, which feed on the algae. Astaxanthin is also an effective antioxidant, which helps eliminating the free radicals in the body, or, for example, protecting the skin from damages & stresses initiated by UV-radiation. Its antioxidant functionality is considerably stronger than vitamin E. Astaxanthin deploys its protective effects not only until inside of the body: it preserves the krill oil already during the storage, e.g. in capsules.

    What particular attention should be paid to when purchasing krill oil?

    For environmental reasons, only the krill oil from sustainable and controlled resources should be considered for a purchase. Last but not least, it’s meaningful to only look after the krill oil, which is proceeded as rapidly as possible after its catch.

    Download Omega-3/Krill-Artcile as PDF

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