Essential Amino Acids

Dr. med. Heinz Lüscher

 

Essential amino acids are not only interesting for athletes! They have various important and complex effects in the human body, which is why they are indispensable for all of us. A deficiency or imbalance in the amino acid balance can lead to serious illnesses.

What are amino acids?

Amino acids are vital for every organism, without them the body could not exist at all. They are the basic building blocks of all proteins that form tissues, such as organs, muscles, etc. Amino acids have other functions, too, such as hormones, precursors of enzymes and neurotransmitters. Thus they are involved in many metabolic processes. Most proteins in the diet consist of chains of over a hundred amino acids. In the stomach they are broken down into smaller chains in an acidic environment with the help of the enzyme pepsin. However, as even these polypeptides cannot yet be absorbed by the intestines, the splitting process (also called hydrolysis) continues in the intestines. The enzymes trypsin and chymotrypsin are found there, which split off the individual amino acids in the alkaline environment of the intestine and thus make them absorbable. Only hydrolysed, individual amino acids can enter the blood through the intestinal wall.

Essential and non-essential amino acids

Of the 20 so-called proteinogenic amino acids (amino acids that occur in proteins), eight are essential. Essential amino acids (or EAA - Essential Amino Acids) are those amino acids that the body needs but cannot produce itself. They must be supplied by the diet. These are the following amino acids: leucine, isoleucine, valine, methionine, phenylalanine, lysine, threonine, and tryptophan. Certain amino acids (e.g. arginine and histidine) are often referred to as semi-essential. These amino acids are only needed by the body in certain situations, e.g. when growing up or during recovery. Semi-essential, or non-essential amino acids, are what the body can make from essential amino acids, but less and less sufficient as we get older. Non-essential amino acids are: Alanine, arginine, asparagine, aspartic acid, cysteine, glycine, glutamine, glutamic acid, serine, tyrosine, proline.

L or D form

Protein-forming amino acids basically (there are few exceptions) occur in two chemical structures, or forms, namely the L-form or the D-form. L-amino acids are "left-turning" (levo, left), D-amino acids are "right-turning" (dextro, right) and a mixture of the two forms is called racemic form. In principle, the organism can only continue to use the L-form, as it only has the right enzymes for this.

Balanced amino acid balance

It is very important for the human body to have a balanced amino acid balance. Otherwise it can have enormous effects on the immune system, the energy balance, as well as the structure and functionality of the body. An increased demand for essential amino acids is present in the following situations: In vegetarians and vegans, children and adolescents, pregnant and breastfeeding women, senior citizens, the overweight, athletes, in stress and certain diseases.

In the following, I will briefly explain the various effects of the individual essential amino acids:

Leucine, isoleucine and valine

These three amino acids are very similar in their effects and together they form a strong team. Because of their structure, they belong to the so-called Branched Chain Amino Acids (BCAA). These three are very important for muscle building as they have many properties that can have a positive effect on protein synthesis. After physical exertion they prevent the breakdown of proteins in the body, which has a positive effect on muscle maintenance. In major physical stress situations, such as operations or injuries, Valin prevents increased protein breakdown. This also has an influence on wound healing and resistance to infections. Leucine, isoleucine and valine also have a positive effect on the body's own energy production. During or after intensive sporting activities, they inhibit the breakdown of glucose in the body. They stimulate insulin secretion and ensure the regulation of blood sugar. In situations in which the body is exposed to particularly high stress, they serve as a source of energy. Even in situations where both the carbohydrate reserves and the fat stores are depleted, high-energy glucose can be produced from the three amino acids leucine, isoleucine and valine. They are therefore very suitable during diets. They increase the basic energy metabolism and actively support weight loss. BCAA are also involved in the release of the growth hormone somatotropin. During puberty, this hormone regulates bone growth in particular, and with increasing age it has a direct influence on the ratio of muscle tissue to fat cells. In the central nervous system, valine also acts as an important precursor of the messenger substances that transfer information and stimuli from one nerve cell to another. Much more can be expected from BCAA, e.g. they play an important role in liver diseases and patients suffering from a mental illness such as schizophrenia can also benefit from them.

Methionine

Methionine is involved in various bodily functions. Among other things, it contributes to the formation of various substances in the body, such as hormones, neurotransmitters and nucleic acids. Methionine is a precursor of the amino acids taurine and cysteine and the antioxidant glutathione. The metabolically active form of methionine is S-adenosyl-methionine, which is found in almost all body tissues and fluids. It is needed for the synthesis, stimulation and breakdown of many substances in the body, particularly active in the brain. Methionine also supports the regeneration of the liver and kidneys. It has an antioxidant effect and can accelerate the breakdown of toxins.

Phenylalanine

Phenylalanine is involved in the production of important endogenous substances. It is the precursor of many hormones and also forms the precursor of the amino acid tyrosine, from which in turn various catecholamines, hormones and neurotransmitters are formed.

Lysine

Lysine also has various functions. For example, it contributes to the formation of enzymes, hormones and antibodies and promotes cell division. It is effective against viruses, e.g. herpes viruses, which are responsible for cold sores, among other things. It promotes bone growth, is involved in the formation of collagen and supports fat metabolism. It also promotes the healing of wounds. Children and young people have an increased need for this essential amino acid compared to adults.

Threonine

The amino acid threonine also has various functions. It plays an important role for the immune system, as it is needed for the formation of immunoglobulins and antibodies. It also helps to maintain the healthy function of the thymus gland, where the so-called T-lymphocytes (a group of white blood cells that serve as an immune defence) mature. Threonine is an important building block in the chain of protein metabolism and contributes to the production of enzymes and hormones. It is involved in the biosynthesis of vitamin B12 and isoleucine and is used to produce energy during periods of intense physical exertion.

Tryptophan

Tryptophan is used by the body to produce the hormone serotonin. This causes the body to fall asleep and to enter into deep sleep and the REM sleep phase. Serotonin also contributes to healthy stress resistance, reduces mood swings and has a mood-lifting effect. Serotonin is also converted into the sleep hormone melatonin, which is important for the functioning of our "inner clock" (circadian rhythm). For the metabolism of tryptophane to serotonin and later to melatonin, some additional cofactors are needed. These include, for example, some vitamins from the B-complex.

Protein metabolism

For a long time it was assumed that proteins mainly produce energy, so we learned that 1 gram of protein releases 4 kcal. Today we know that there is an anabolic and a catabolic metabolic pathway for proteins. In the anabolic pathway, the amino acids are only used to build up protein in the cells, which does not release any energy, so these amino acids are calorie-free. In the catabolic pathway, the proteins are "burned", releasing energy and producing a considerable amount of nitrogen waste. This nitrogen waste (ammonia) has to be broken down in the liver and excreted via the kidneys, which is a great strain on both organs.

Nitrogen waste

During the combustion of amino acids in the body (catabolic metabolic process), a considerable amount of so-called nitrogen waste (90% ammonia, 10% uric acid) is always produced. Both waste products put a strain on the intestines, liver and kidneys. Most vegetarians and vegans rely on soya as a source of protein, while athletes mainly rely on whey. Fitness centres sell large quantities of protein food made from whey for muscle building. So let's look at the amount of nitrogen waste in common foods:

Chicken                                                                        52%

meat, fish                                                                     64-72%

Soya                                                                            83%

Whey                                                                          84%.

Essential amino acids, hydrolysed, from legumes             2%  

Nitrogen waste-free

A suitable dietary supplement containing essential amino acids is therefore a natural food, obtained from legumes, the amino acids already broken down and ready for absorption, calorie-free and practically free of nitrogen waste.  

 Indications for an additional intake of essential amino acids

  • Immunodeficiency
  • Iron deficiency anaemia
  • Type II diabetes
  • Gestational Diabetes
  • Renal insufficiency
  • Liver diseases
  • Bowel problems
  • Heart problems
  • Anorexia
  • Cachexia (terminal stage of cancer, AIDS etc.)
  • Obesity
  • Osteoporosis (together with vitamin D, vitamin K2 and magnesium)
  • Food allergies
  • Multiple Sclerosis
  • Faster healing for fractures

Dosage

Essential amino acids are offered as food supplements or dietary foods. The easiest way to consume them is in the tablet form.

IMPORTANT: The individual amino acids must be hydrolysed. Only then can they be absorbed by the body in less than 30 minutes and cannot cause allergies!

One should take approx. 5 grams of amino acids each with a little water. In case of illness in the morning and during sporting activities 30 minutes before exercise. The recommended maximum dose is 10 grams per day.

Side effects

There are no side effects. Normal proteins can cause allergies or intolerances, but this is not possible with a product made of hydrolysed amino acids.